Effects of hazelnut consumption on blood lipids in hyperlipidemic adults: A RCT

Document Type : Research Paper

Authors

1 Almaty Technological University, Department “Food Biotechnology,” Tole bi 100 St., Almaty, Kazakhstan

2 Kazakh National Women’s Teacher Tranıng University, Gogolya 112/1, Almaty, Kazakhstan

3 Kazakh-Russian Medical University, Department of Anatomy with Physiology Courses, Torekulova St., 13, Almaty, Kazakhstan

4 Institute of Genetics and Physiology, Al-Farabi St., 93, Almaty, Kazakhstan

5 Department of Chemistry, Kazakh National Medical University named afterS.D. Asfendiyarov, Almaty, Kazakhstan

6 Department of Biology, Faculty of Natural Sciences and Geography, Kazakh National Pedagogical University, Almaty, Kazakhstan

10.22124/cjes.2024.7849

Abstract

Hyperlipidemia is a major risk factor for cardiovascular disease, necessitating effective dietary interventions. This randomized controlled trial (RCT) searched the impacts of hazelnut consumption on blood lipids in hyperlipidemic adults, emphasizing innovative approaches to optimize outcomes. Two hundred hyperlipidemic adults were randomized into intervention and control groups. The intervention group received tailored hazelnut doses based on body weight for 12 weeks, while the control group maintained their usual diet. Advanced lipid profiling and biomarker analyses were employed to assess hazelnut bioavailability and lipid metabolism. Hazelnut consumption led to significant improvements in lipid profiles compared to the control group. Participants receiving higher hazelnut doses demonstrated greater reductions in total cholesterol (p < 0.05) and LDL cholesterol (p < 0.01), with sustained effects observed during a 12-week follow-up. Biomarker analyses revealed enhanced bioavailability of beneficial nutrients from hazelnuts, supporting their lipid-lowering effects. This study innovatively explored hazelnut dosing based on body weight to establish a dose-response relationship. Advanced lipid profiling provided mechanistic insights into hazelnut-mediated lipid metabolism changes. Additionally, a behavioral intervention combining hazelnut consumption with dietary counseling enhanced participant engagement and adherence. Hazelnut consumption, particularly at optimized doses, demonstrates promising effects on blood lipids in hyperlipidemic adults. Our findings support the integration of hazelnuts into personalized dietary recommendations for lipid management.

Keywords

References

Alfred-Iyamu, T 2024, Self-management of coronary heart disease among middle-aged and older low-income African Americans.
Babashev, A, Tumaevna, MA, Nauryzbaevish, AS, Maralovich, KA, Utegaliyeva, R, Yeshmukhanbet, A, Yessenova, M & Amangeldinovna, ZA 2023, A physiological characterization of the high-fat diet on the induction of obesity in adult male Swiss mice. Caspian Journal of Environmental Sciences, 21: 931-938.
Brown, R, Ware, L & Tey, SL 2022, Effects of hazelnut consumption on cardiometabolic risk factors and acceptance: A systematic review. International Journal of Environmental Research and Public Health, 19(5): 2880.
Buckley, BJ, Harrison, SL, Lane, DA, Hill, A & Lip, GY 2024, Stroke–heart syndrome: mechanisms, risk factors, and adverse cardiovascular events. European Journal of Preventive Cardiology, 31: e23-e26.
Cai, A, Nie, Z, Ou, Y, Wang, J, Chen, Y, Lu, Z, Liang, Y, Zhou, Y & Feng, Y 2022, Association between sociodemographic status and cardiovascular risk factors burden in community populations: implication for reducing cardiovascular disease burden. BMC Public Health, 22: 1996.
Castro, RR, Sales, ARK & Nóbrega, A C 2020, Lifestyle interventions reduce exercise ventilatory variability in healthy individuals: a randomized intervention study. Future Cardiology, 16: 439-446.
Chaker, A, Suarez, PA, Remila, L, Bruckert, C, Park, S, Houngue, U, Belcastro, E, Qureshi, A, El Itawi, H & Toti, F 2020, Anthocyanin-rich blackcurrant intake by old rats improves blood pressure, vascular oxidative stress and endothelial dysfunction associated with SGLT1-and 2-mediated vascular uptake of anthocyanin. Archives of Cardiovascular Diseases Supplements, 12(2-4): 221.
da Silva Anastacio, V 2024, Nutrigenetics & nutrigenomics and its clinical application St Mary's University.
Dayrit, FM 2024, The lipid-heart hypothesis and the keys equation defined the dietary guidelines but ignored the impact of trans-fat and high linoleic acid consumption.
Garg, ML, Blake, RJ & Wills, RB 2003, Macadamia nut consumption lowers plasma total and LDL cholesterol levels in hypercholesterolemic men. The Journal of Nutrition, 133: 1060-1063.
Ginos, BN, Navarro, SL, Schwarz, Y, Gu, H, Wang, D, Randolph, TW, Shojaie, A, Hullar, MA, Lampe, PD & Kratz, M 2018, Circulating bile acids in healthy adults respond differently to a dietary pattern characterized by whole grains, legumes and fruits and vegetables compared to a diet high in refined grains and added sugars: A randomized, controlled, crossover feeding study. Metabolism, 83: 197-204.
Goyal, P, Balkan, L, Ringel, JB, Hummel, SL, Sterling, MR, Kim, S, Arora, P, Jackson, EA, Brown, TM & Shikany, JM 2021, The Dietary Approaches to Stop Hypertension (DASH) diet pattern and incident heart failure. Journal of Cardiac Failure, 27: 512-521.
Jakše, B, Godnov, U, Fras, Z & Fidler Mis, N 2024, Associations of dietary intake with cardiovascular risk in long-term “plant-based eaters”: A secondary analysis of a cross-sectional study. Nutrients, 16: 796.
Jeong, D & Priefer, R 2022, Anti-obesity weight loss medications: Short-term and long-term use. Life Sciences, 306: 120825.
Liang, K & Dai, J-Y 2022, Progress of potential drugs targeted in lipid metabolism research. Frontiers in Pharmacology, 13: 1067652.
Magno, S, Ceccarini, G, Pelosini, C, Jaccheri, R, Vitti, J, Fierabracci, P, Salvetti, G, Airoldi, G, Minale, M & Saponati, G 2018, LDL-cholesterol lowering effect of a new dietary supplement: an open label, controlled, randomized, cross-over clinical trial in patients with mild-to-moderate hypercholesterolemia. Lipids in Health and Disease, 17: 1-8.
Moghadam, SG, Pour, ME, Alavizadeh, SH, Kesharwani, P & Sahebkar, A 2024, The association between oxidized low-density lipoprotein and cancer: An emerging targeted therapeutic approach? Bioorganic & Medicinal Chemistry Letters, 129762.
Nazari, A, Kounis, NG, Ahmadi, Z & Pourmasumi, S 2024, Nuts and Nutritional Factors in Management of Male Fertility: A Review. International Journal of Nutrition Sciences. 9: 1-13
Ogura, M, Okazaki, S, Okazaki, H, Tada, H, Dobashi, K, Nakamura, K, Matsunaga, K, Miida, T, Minamino, T, & Yokoyama, S 2024, Transitional medicine of intractable primary dyslipidemias in Japan. Journal of Atherosclerosis and Thrombosis, 31: 501-519.
Oras, P, Häbel, H, Skoglund, PH & Svensson, P 2020, Elevated blood pressure in the emergency department: a risk factor for incident cardiovascular disease. Hypertension, 75: 229-236.
Perez-Beltran, YE, Rivera-Iniguez, I, Gonzalez-Becerra, K, Perez-Naitoh, N, Tovar, J, Sayago-Ayerdi, SG & Mendivil, EJ 2022, Personalized dietary recommendations based on lipid-related genetic variants: a systematic review. Frontiers in Nutrition, 9: 830283.
Raber, I & Gelfand, EV 2022, Hypoglycemic therapies and reducing CVD risk. In: Handbook of Outpatient Cardiology (pp. 193-210), Springer.
Razavi, AC, Jain, V, Grandhi, GR, Patel, P, Karagiannis, A, Patel, N, Dhindsa, DS, Liu, C, Desai, SR & Almuwaqqat, Z 2024, Does elevated high-density lipoprotein cholesterol protect against cardiovascular disease? The Journal of Clinical Endocrinology & Metabolism, 109: 321-332.
Saffar Shargh, A, Zakipour Rahimabadi, E, Alizadeh, E & Gheybi, F 2017, Amino acid and fatty acid profiles of materials recovered from Prussian carp, Carassius gibelio (Bloch, 1782), using acidic and basic solubilization/precipitation technique. Caspian Journal of Environmental Sciences, 15: 285-294
Salimi, S & Kuşcu, GS 2023, Factors influencing cardiovascular patients' knowledge of CVD risk factors. Journal of Vascular Nursing, 41: 121-124.
Samuel, PO, Edo, GI, Emakpor, OL, Oloni, GO, Ezekiel, GO, Essaghah, AEA, Agoh, E & Agbo, JJ 2024, Lifestyle modifications for preventing and managing cardiovascular diseases. Sport Sciences for Health, 20: 23-36.
Sandesara, PB, Virani, SS, Fazio, S & Shapiro, M D 2019, The forgotten lipids: triglycerides, remnant cholesterol, and atherosclerotic cardiovascular disease risk. Endocrine Reviews, 40: 537-557.
Willeit, P, Yeang, C, Moriarty, P, Tschiderer, L, Varvel, S, Mcconnell, J & Tsimikas, S 2020, LDL-cholesterol corrected for LP (A)-cholesterol, risk thresholds and cardiovascular events. Atherosclerosis, 315: e34-e35.
Wu, Y, Sun, H, Yi, R, Liao, X, Li, J, Li, H, Tan, F & Zhao, X 2020, Malus hupehensis leaves extract attenuates obesity, inflammation, and dyslipidemia by modulating lipid metabolism and oxidative stress in high‐fat diet‐induced obese mice. Journal of Food Biochemistry, 44: e13484.
Xie, Y, Jiang, Y, Wu, Y, Su, X, Zhu, D, Gao, P, Yuan, H, Xiang, Y, Wang, J & Zhao, Q 2024, Association of serum lipids and abnormal lipid score with cancer risk: A population-based prospective study. Journal of Endocrinological Investigation, 47: 367-376.
Caspian Journal of Environmental Sciences
Volume 22, Issue 3
July 2024
Pages 627-637

Files

Share

How to cite

Statistics