Effect of Ibuprofen, Ponstan and Panadol oral suspensions on the gastrointestinal mucosal layer in mice

Document Type : Research Paper

Author

Biology Department, Science College, Mustansiriyah University, Baghdad, Iraq

10.22124/cjes.2022.5687

Abstract

Antipyretic drugs such as suspensions of mefenamic acid (ponstan), Ibuprofen and paracetamol (acetaminophen) are the most common drugs that wildly used in children to decrease the fever, pain and inflammation. From clinical observations of children using these drugs, they cause gastrointestinal complications and from this, the idea of this research was to find the effect of these drugs on the mucous membrane of the gastrointestinal tract in Swiss albino mice. In the present study, we used 30 mice classified into five groups including G1 as control group, G2 received 15 mg/kg/day panadol, G3, 30 mg/kg/day ibuprofen, G4, 5 mg/kg/day ponstan and G5, a combination of panadol and ibuprofen in the same previously- mentioned doses for 7 days respectively. The gastric histological sections of G2 exhibited normal mucosal; G4 displayed mild mucosal glandular hyperplasia; while G3 and G5 e appeared flat mucosal surface with submucosal hyperplasia of gland mild atypical cells; and G2 revealed mucosal glandular hyperplasia. The intestine histological sections of G2 appeared normal intestinal villi with mild inflammatory cells infiltration; G3 showed dispersed slight shortening of intestinal villi with mild inflammatory cells infiltration; finally, G4 and G5 indicated villi hyperplasia with a slight widening of villi with mild inflammatory cells infiltration. NSAIDs are available over-the-counter drugs for adult and in paediatric population and are considered as a safe medicine if used in properly dose in the short-term. The decision to pick an antipyretic should be dictated by safety, efficacy, effectiveness, duration of action and the integrity of the patient gut.

Keywords

References

Ahluwalia, A, Jones, MK, N &   Tarnawski, AS 2019, Mitochondria in gastric epithelial cells are the key targets for NSAIDs‐induced injury and NGF cyto-protection. Journal of Cellular Biochemistry, 120: 11651-11659.
Alexander, KCL, Kam, LH & Theresa, NHL 2018, Febrile seizures: An overview. Drugs Context, 7: 212536.  DOI: 10.7573/dic.212536.
 Balasubramanian, S & Sumanth, A 2010, Mefenamic acid – Role as Antipyretic. Indian paediatrics. May, 17, Vol. 47: 453.
Bancroft, JD, Stevens, A, & Turner, DR 1996, Theory and practice of   histological techniques. 4th Edition, Churchill Livingstone, London, Toronto.
Bernard, B 2004, Gastrointestinal safety of paracetamol: Is there any cause for     concern? Journal of Expert Opinion on Drug Safety, 3: 269-272.
Bjarnason, I, Scarpignato, C, Erik, H, Michael, O, Kim, DR & Angel, L 2018, Inflammatory drugs, Gastroenterology, 154: 500-514.
Bunchorntavakul, C & Reddy, KR 2013, Acetaminophen-related hepatotoxicity.  Clinical Liver Disease, 7: 587-607.
Charles, NF, Estella TF, Kechia, F, Bathelemy, N & Bonaventure, NO 2018, Overview of non-steroidal anti-inflammatory drugs (NSAIDs) in resource limited countries. MOJ Toxicology, 4: 5-13. DOI:10.15406/mojt.2018.04.00081.
Chiappini, E, Parretti, A & Becherucci, P et al. 2012, Parental and medical knowledge and   management of fever in Italian pre-school children.  BMC Paediatric. 12: 97, [http://dx.doi.org/10.1186/1471-2431-12-97].
Eefje, GP, de, B, Julie, MML, Dagmar, ASH, Nicole, L, Yvonne, GH, Geert-Jan, D & Jochen, WLC 2015, Work load and management of childhood fever at general practice out-of-hours care: an observational cohort study, BMJ Open. 5(5): e007365. DOI: 10.1136/bmjopen-2014-007365.
Falavigna, M, Stein, PC, Flaten, GE & Di Cagno, MP 2020, Impact of mucin on drug diffusion: development of a straightforward in vitro method for the determination of drug diffusivity in the presence of mucin pharmaceutics, 12(2), 168.
Ghanem, CI, Perez, MJ, Manautou, JE & Mottino, AD  2016, Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. Pharmacological Research, 109: 119-131.
Huang, C, Lu, B, Yi-Hong, F, Zhang, L, Jiang N, Zhang, S & Li- Na, M 2014, Muscovite is protective against non-steroidal anti-inflammatory drug- induced small bowel injury. World Journal of Gastroenterology, 9; 21; 20(31).
Ito, Y, Yukinari, T, Yanagawa, A & Nakagawa, T 1992, NSAIDs (non- steroidal anti-inflammatory drugs) for the treatment of rheumatoid arthritis. Nihon Rinsho Japanese Journal of Clinical Medicine, 50: 509-514.
Kalra, BS, Chaturvedi, S, Tayal, V & Gupta, U 2009, Evaluation of gastric        tolerability, anti-nociceptive and anti-inflammatory activity of combination NSAIDs in rats. Indian Journal of Dental Research, 20: 418.
Kanabar, DJ 2017, A clinical and safety review of paracetamol and ibuprofen in children, Inflammopharmacology. 25: 1-9.
Klotz, U. 2012, Paracetamol (acetaminophen)-a popular and widely used nonopioid analgesic, Arzneimittel-Forschung, 62: 355-359, DOI: 10.1055/s   0032-1321785.
Kunkulol, RR, Sonawane, A, Ashok & KCh 2013, Evaluation of efficacy and tolerability of acetaminophen (paracetamol) and mefenamic acid as antipyretic in patients with febrile illness: A comparative study. International Journal of Medical Research & Health Sciences, 2: 23-29.
Marginean, CO, Meliţ, LE & Chinceşan, M 2017, Communication skills in paediatrics - the relationship between paediatrician and child. Medicine (Baltimore) 96: e8399.
Marhamah, F, Singgih, Huldani, Harun, A, Bayu, IS, Austin, BC, Aminuddin, PP, Sri R & Andika, PP 2020, A review of nonsteroidal anti- inflammatory drugs (NSAIDs) medications in dentistry: Uses and side     effects. Systematic Reviews in Pharmacy, 11: 293-298.
Maria, OM, Lorena, EM, Simona, M & Vladuț, S 2018, Ibuprofen, a   potential cause of acute haemorrhagic gastritis in children - A case report. The Journal of Critical Care Medicine (Targu Mures). 4: 143-146, DOI: 10.2478/jccm-2018-0022.
Rao, CV, Sairam, K & Goel, RK. 2000, Experimental evaluation of Bocopa   monniera on rat gastric ulceration and secretion. Indian Journal of Physiology and Pharmacology, 44: 435441.
Rostom, A, Dube, C, Wells, GA, Tugwell, P, Welch, V, Jolicoeur, E & Lan A 2002, Prevention of NSAID‐induced gastroduodenal ulcers. Cochrane database of systematic reviews. 4 DOI: 10.1002/14651858.CD002296.    
Sahib, AEl  2019, Pathogenesis of fever. Clinical Manual of Fever in Children, 2: 53-68, DOI: 10.1007/978-3-319-92336-9_3.
Singla, NK, Parulan, C & Samson, R et al. 2012, Plasma and cerebrospinal fluid pharmacokinetic parameters after single-dose administration of intravenous, oral, or rectal acetaminophen. Pain Practice, 12: 523-532, DOI:10.1111/j.1533-2500.2012.00556.x.
Sostres, C, Gargallo, CJ & Lanas, A 2013, Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Research & Therapy, 15 Suppl. 3 (Suppl. 3), S3. https://doi.org/10.1186/ar4175.
Struct, BJ 2016, The structure of ibuprofen bound to cyclooxygenase-2, Journal of Structural Biology, 189: 62-66, DOI: 10.1016/ j.jsb.2014.11.005.
Wallace, JL 2008, Prostaglandins, NSAIDs, and gastric mucosal protection: Why    doesn't the stomach digest itself? Physiological Reviews, 88: 1547-1565.
Woessner, KM & Castells, M 2013, NSAID single–drug–induced reactions. Immunology and Allergy Clinics of North America, 33: 237-249.
Caspian Journal of Environmental Sciences
Volume 20, Issue 3
July 2022
Pages 539-544

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