The role of mast cells, C-fibers, and cholinergic transmission in the reduction of tracheal muscle and mronchi of sensitized animal

Document Type : Research Paper

Authors

Department of Life Safety and Health-saving Technologies, Federal State Budgetary Educational Institution of Higher Education «Petrozavodsk State University, Petrozavodsk, The Republic of Karelia, the city of Petrozavodsk, Russia

Abstract

The article considers the role of stabilization of mast cell membranes, blockade of neuromuscular transmission and inactivation of C-fibers in the contractile activity of smooth muscles of the trachea and bronchi of sensitized rats. The studies were conducted on isolated preparations using electrical stimulation of postganglionic nerves (frequency - 30 stim/s, duration - 0.5 ms, amplitude - 20 V, duration of stimulation - 10 s). The study used cromolyn sodium, atropine, and capsaicin. As a result of the experiments, it was found that the leading role in the contraction of the muscles of the trachea and bronchi of a sensitized rat belongs to mast cells. However, the maximum effect of normalization of smooth muscle contraction can be achieved only in the case of a complex effect - blockade of neuromuscular transmission, stabilization of mast cell membranes, and inactivation of C-fibers.

Keywords

References

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Caspian Journal of Environmental Sciences
Volume 18, Issue 5
Special Issue: Environmental Aspects of Economic and Social Sustainable Development
December 2020
Pages 495-502

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