TY - JOUR ID - 4477 TI - The role of mast cells, C-fibers, and cholinergic transmission in the reduction of tracheal muscle and mronchi of sensitized animal JO - Caspian Journal of Environmental Sciences JA - CJES LA - en SN - 1735-3033 AU - Kirilina, V.M. AU - Blazhevich, L.E. AU - Smirnova, O.E. AD - Department of Life Safety and Health-saving Technologies, Federal State Budgetary Educational Institution of Higher Education «Petrozavodsk State University, Petrozavodsk, The Republic of Karelia, the city of Petrozavodsk, Russia Y1 - 2020 PY - 2020 VL - 18 IS - 5 SP - 495 EP - 502 KW - Romolyn sodium KW - Atropine KW - Capsaicin KW - Acetylcholine receptor blockade KW - Electrical stimulation KW - Postganglionic nerves DO - 10.22124/cjes.2020.4477 N2 - The article considers the role of stabilization of mast cell membranes, blockade of neuromuscular transmission and inactivation of C-fibers in the contractile activity of smooth muscles of the trachea and bronchi of sensitized rats. The studies were conducted on isolated preparations using electrical stimulation of postganglionic nerves (frequency - 30 stim/s, duration - 0.5 ms, amplitude - 20 V, duration of stimulation - 10 s). The study used cromolyn sodium, atropine, and capsaicin. As a result of the experiments, it was found that the leading role in the contraction of the muscles of the trachea and bronchi of a sensitized rat belongs to mast cells. However, the maximum effect of normalization of smooth muscle contraction can be achieved only in the case of a complex effect - blockade of neuromuscular transmission, stabilization of mast cell membranes, and inactivation of C-fibers. UR - https://cjes.guilan.ac.ir/article_4477.html L1 - https://cjes.guilan.ac.ir/article_4477_ae492cb8b8f54e5df47435bb268f71a6.pdf ER -