Influence of butylcaptax and Dropp on the phospholipid composition and lipid peroxidation (LPO) in the liver mitochondria and microsomes of pregnant rats and their embryos

Document Type : Research Paper

Authors

1 Department of Biological Chemistry and Pharmacy, Andijan Branch of Kokand University, Andijan

2 Department of Biology, Faculty of Natural Sciences, National Pedagogical University of Uzbekistan named after Nizami, Tashkent City, Uzbekistan

3 Department of Biochemistry and Physiology, Tashkent State Agrarian University, Tashkent State Agrarian University, Tashkent region, Uzbekistan

4 Rector of Chirchik State Pedagogical University, Tashkent, Uzbekistan

5 Department of Faculty and Hospital Surgery No.1, Tashkent State Medical University, Tashkent, Uzbekistan

6 Department of Microbiology, Immunology and Virology, Andijan Branch of Kokand University, Andijan, Uzbekistan

7 Department of Inorganic, physical and colloidal chemistry, Tashkent Pharmaceutical Institute, Tashkent, Uzbekistan

8 Department of basic medical sciences Faculty of Medicine, Termez University of Economics and Service, Termez, Uzbekistan

10.22124/cjes.2026.9616

Abstract

This study investigates the effects of the defoliants butylcaptax and Dropp on the phospholipid composition and lipid peroxidation (LPO) in the liver mitochondria and microsomes of pregnant rats and their embryos. Experiments were conducted on Wistar rats exposed to 1/10 of the LD50 dose on gestation days 3, 13, and 19. The results demonstrated a decrease in phosphatidylethanolamine and total phospholipid content, along with an increase in phosphatidic acid, lysophospholipids, and the cholesterol/phospholipid ratio. A significant enhancement of both enzymatic and non-enzymatic LPO was observed in the mitochondria and microsomes, with more pronounced effects following butylcaptax exposure. Although embryonic tissues exhibited less marked alterations, similar trends were observed. The findings indicate the activation of lipid peroxidation processes and the disruption of membrane structures, which may contribute to embryotoxic effects.

Keywords

References

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Caspian Journal of Environmental Sciences
Volume 24, Issue 2
April 2026
Pages 305-318

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