Evaluation of male rats' genital system alterations caused by cadmium with consumption of total methanolic extract of orange peel

Articles in Press

Document Type : Research Paper

Authors

1 Associate Professor of the Department of Hygiene No.2 of the Bukhara State Medical Institute named after Abu Ali Ibn Sino, Uzbekistan

2 Kimyo International University in Tashkent Shota Rustaveli Street 156, 100121, Тashkent, Uzbekistan

3 Professor, Doctor of Technical Sciences, Tashkent State Transport University, Tashkent, Uzbekistan

4 Department of General Professional Science, Mamun University, Khiva, Uzbekistan

5 Assistant Professor, Navoi State University of Mining and Technologies, Navoi, Uzbekistan

6 Associate Professor, Jizzakh State Pedagogical University, Jizzakh, Uzbekistan

7 Doctor of Medical Sciences, Professor, Head of the Department of Otorhinolaryngology FPDO. Samarkand State Medical University, Samarkand, Uzbekistan

8 Pharmaceuticals and Chemistry, Faculty of Medicine, Alfraganus University, Tashkent, Uzbekistan

9 Head of the Department of Hydraulic Installations and Pumping Stations, Karshi State Technical University, Kashkadarya, Uzbekistan

10 Professor of the Department of General Surgery, Anesthesiology- Reanimatology and Ophthalmology, Andijan State Medic. al Institute, Andijan, 170100, Uzbekistan

10.22124/cjes.2025.8812

Abstract

Cadmium (Cd) is a hazardous heavy metal devoid of any essential biological function, presenting considerable risks to both human and animal health, even at minimal exposure levels. This investigation examines the influence of cadmium on the male reproductive system of rats. It assesses the probable preserving effects of the total methanolic extract derived from orange peel, Citrus sinensis. The research underscores that cadmium, a common environmental contaminant from industrial processes, can accumulate in biological tissues, particularly within the testes, leading to reproductive toxicity and structural impairments. The study involved administering cadmium chloride to male rats at a concentration of 2 mg kg-1, while a separate cohort received orange peel extract (250 mg kg-1). The experimental period lasted eight weeks, with daily treatments delivered via gavage. The results revealed significant changes in liver enzyme levels, indicating hepatic damage and oxidative stress associated with cadmium exposure. Conversely, the administration of orange peel extract exhibited both protective and restorative effects against liver toxicity induced by cadmium, as demonstrated by a decrease in oxidative stress markers. These outcomes highlight the possibility of the orange peel as an expected intervention to alleviate the detrimental effects of cadmium toxicity in the male reproduction system. This research enhances the understanding of cadmium influence on male reproductive health and emphasizes the therapeutic advantages of natural extracts in addressing heavy metal-induced harm. Overall, the study underscores the necessity of investigating natural products' protective capabilities against environmental toxins, thereby paving the way for future inquiries in this domain.

Keywords

References

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Caspian Journal of Environmental Sciences

Articles in Press, Corrected Proof
Available Online from 04 June 2025

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