Document Type : Research Paper
Authors
1
Faculty of Natural Sciences and Agrobiotechnology, Department of Doctor of Philosophy (PhD), Senior Lecturer in Biology, Bukhara State University, Bukhara, Uzbekistan
2
Deparyment of Neurology and Psychiatry, Fergana Medical Institute of Public Health, Fergana, Uzbekistan
3
Dotsent, Department of “General and Pediatric Surgery”, Tashkent Medical Academy, Tashkent, Uzbekistan
4
Assistant, Department of Agronomy, Navoi State University of Mining and Technologies, Navoiy, Uzbekistan
5
PhD, Assistant, Department of Neurology, Samarkand State Medical University, Samarkand, Uzbekistan
6
Associate Professor, Tashkent State Technical University, Tashkent, Uzbekistan
7
PhD, Senior Teacher, Department of Pharmaceuticals and Chemistry, Faculty of Medicine, Alfraganus University, Tashkent, Uzbekistan
8
PhD, Law Enforcement Academy of the Republic of Uzbekistan
9
Lecturer, Department of Art Science, Karakalpak State University named after Berdak, Nukus, Republic of Karakalpakstan
10
Kimyo International University in Tashkent, Shota Rustaveli Street 156, 100121, Тashkent, Uzbekistan
10.22124/cjes.2025.8733
Abstract
Cadmium (Cd) is an environmental contaminant linked to various health issues, particularly in reproductive health. Garlic (Allium sativum) is noted for its numerous health benefits, including its potential positive effects on women's reproductive health. Despite its recognized therapeutic properties, research specifically addressing garlic's impact on the female reproductive system remains limited, prompting the need for further investigation into its protective effects against cadmium-induced toxicity. This study investigates the protective effects of methanolic garlic extract (GE) against cadmium (Cd) toxicity in female rats, focusing on its impact on hematological and biochemical parameters, as well as histopathological changes in the uterus. A total of twenty-one healthy female mice were divided into three groups: one receiving Cd treatment, another receiving GE, and a control group. The experiment lasted eight weeks, during which various parameters were assessed. Results indicated that Cd exposure led to significant increases in liver enzymes (SGPT, SGOT, ALP) and caused moderate edema in the endometrium, characterized by the separation of endometrial stromal cells and hyperplasia of the uterine mucosa and glandular epithelium. Conversely, treatment with GE at a dosage of 300 mg/kg resulted in a statistically significant reduction in these liver enzyme levels and ameliorated the histopathological changes in the uterus, including decreased edema and hyperplasia. Additionally, hematological assessments revealed that GE treatment normalized the counts of red blood cells, white blood cells, and lymphocytes, which were adversely affected by Cd exposure. The findings suggest that garlic extract possesses detoxifying properties that can mitigate the adverse effects of cadmium on the female reproductive system. This research highlights the potential of incorporating garlic into dietary practices or using it as an adjunct in chelation therapy for Cd toxicity treatment, emphasizing its beneficial role in maintaining reproductive health and liver function in the context of heavy metal exposure.
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