Antidermatophytal efficacy of the secondary metabolites extracted from Citrullus colocynthis L. fruits

Document Type : Research Paper

Authors

Department of Biology, College of Science for Women, University of Babylon, Iraq

10.22124/cjes.2024.7504

Abstract

The present study, was conducted to investigate the effect of the crude Alkaloids, Terpenoids, and Flavonoids compounds extract from fruits of Citrullus colocynthis L. against Dermatophytes species such as Chrysosporium sp, Trichophyton mentagrophytes, Microsporum canis, Trichophyton quinckeanum, and Trichophyton interdigitale isolated from clinical samples in the province of Babil 2022 in Iraq. Antifungal activity was achieved in vitro by using food poisoning method against Dermatophytes species by preparing three concentrations for each crude compound (5, 10, and 15) mg/ml and compared with positive control represented by Fluconazole 150mg and a negative control represented by 10% dimethyl sulfoxide. The aim of this study was to control of Dermatophytes species isolated from clinical samples by using secondary metabolites extracted from fruits of Citrullus colocynthis L.  The data collected from the study revealed that, the crude Alkaloids, Terpenoids, and Flavonoids compounds extract from fruits of Citrullus colocynthis L. showed significant reduction at P≤ 0.05 in the growth of Dermatophytes species especially at 15 mg/ml compared with negative control and the same effects compared with the Fluconazole. Finally, it can be concluded that Citrullus colocynthis L.  is most effective in controlling Dermatophytes species.

Keywords

Caspian Journal of Environmental Sciences

Articles in Press, Corrected Proof
Available Online from 04 February 2024

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