Evaluation the anticancer and biological activity by new amide compound of trimethoprim with some of its complexes

Document Type : Research Paper


Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq



By reacting trimethoprim and hippuric acid at a molecular weight of 1, the amide ligand molecule was produced. By reacting ligands with CoCl2.2H2O, NiCl2.6H2O, and K2PtCl6 in a 2:1 [L:M] mole ratio, cobalt (II), nickel (II), and platinum (IV) complexes were produced. All of the produced compounds were studied by taking readings of their FT-IR, UV-Vis, TG/DTA, 1H-NMR, CHN, melting point, molar conductivity, magnetic susceptibility, and chloride. All the synthesized compounds had anticancer, antibacterial, and antifungal activities against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida, respectively.


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