Effects of sophoroflavonoside and narcissin flavonoids on the amount of malondialdehyde, a product of lipid peroxidation, and the activity of the enzyme cytochrome c oxidase in rat liver mitochondria poisoned with indoxacarb pesticide

Authors

1 Andijan State University, Andijan City

2 Tashkent State Pedagogical University Named after Nizomi, Tashkent City

3 M. Ulugbek National University of Uzbekistan, Tashkent City

4 Tashkent State Agrarian University, Tashkent City, Republic of Uzbekistan

10.22124/cjes.2023.7159

Abstract

In this study, the effects of soforaflavonolonoside and narcissin flavonoids on the amount of malondialdehyde, a product of peroxidation of lipids in the liver mitochondria of rats poisoned with indoxacarb pesticide, and on the activity of the enzyme cytochrome-s-oxidase were studied depending on the dynamics of 10, 20, 30 and 40 days. The experimental group was injected with indoxacarb pesticide at a dose of 1/10 LD50 through a special probe. After administration of indoxacarb pesticide, animals were administered orally with soforaflavonolonoside and narcissin flavonoid at a dose of 10 mg kg-1 once a day for 10 days.

Keywords


Assi, MA, Mohammed, MH, Abdulkahaleq, LA 2022, Evaluate the effect of alcoholic extraction of walnut on gonadal hormones of treated rats. Caspian Journal of Environmental Sciences, 20: 145-153.
Akinshina, NG & Gudnikova, AG 2003, On the mechanism of action of a pyrethroid preparation on the functional state of isolated rat liver mitochondria. Toxicological Bulletin Moscow, 1: 28-32, [In Russian].
Alimbabaeva, NT, Mirkhamidova, P, Isabekova, MA, Zikiryaev, A & Fayzullaev, SS  2005, The effect of residual amounts of karate on the activity of mitochondrial enzymes of hepatocytes. Uzbek Biological Journal, 4: 15-19, [In Uzbekistani].
Dzhurabekova, ZI & Saidov, BM 2015, Pesticides and health. Collection of the Conference on the topic of increasing the effectiveness of biological methods in protecting plants from harmful organisms, and their prospects, Tashkent, pp. 56-57, [In Uzbekistani].
Dremova, VP 2011, WHO classification of pesticides according to their degree of danger. Medical  Parasitology and Parasitic Diseases, 3: 53-54, [In Uzbekistani].
Parpieva, MZh, Mirkhamidova, P, Pozilov, MK & Nishanbaev, SZ 2022, Determination of antiradical activities of sophoroflavonoside and narcissin flavonoids. Infection, Immunity and Pharmacology, 4: 180-186, [In Uzbekistani].
Rogozhin, VV 2013, Workshop on biochemistry: Textbook. St. Petersburg: Publishing house "LAN", 544 p, [In Russian].
Khzhaev, ShT, Isaev, O & Yuldashev, F 2009, Avaunt's capabilities. Plant Protection and Quarantine, 2 (12), [In Uzbekistani].
Franco R , LiS, Rodriguez-Rocha, H , Burns, M  & Panayiotidis, MI  2010, Molecular mechanisms of pesticide-induced neurotoxicity: Relevance to Parkinson's disease.  Chemico-Biological Interactions, 188: 289.
Mirkhamidova, P, Pozilov, MK, Parpieva, MJ, Shakhmurova,  GA & Jumagulova KA 2022, Determination of the amount of residual pesticides in the liver tissue of rats poisoning with haloxyphop-r-methyl and indosacarb pesticides. Journal of Pharmaceutical Negative Results,13: 738-745
Mirkhamidova, P, Tuychieva, D, Bobokhonova,  D & Parpieva, M 2020,  Influence of karate on the activity of enzymes of the anti-oxidizing system of rat liver protection and ways of their correction. European Journal of Molecular & Clinical Medicine. 7: 3757-3765.  
Parpiyeva, MJ, Mirxamidova, P, Pozilov, MK & Tuychiyeva, DS 2022, The effect of phlavonoids on precisely oxidation of lipids of the membrane of the rat liver mitochondria, poisoned with pesticides. Jundishapur Journal of Microbiology, Published online 15: 676-681.
Toualbia, N, Rouabhi, R & Salmi, A 2017, Evaluation of cytochrome c level and mitochondrial dysfunction biomarkers of Oryctolagus cuniculus liver exposed to Chlorpyrifos. Toxicology and Environmental Health Sciences, 9: 325-331.