Effect of Curcuma longa and its derivatives, curcumin and curcuminoids on treatment of oral lichen planus: A systematic review of clinical evidence

Document Type : Reviewers

Authors

1 Student Research Committee, Zahedan University of Medical Sciences, Zahedan. Iran

2 Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

10.22124/cjes.2023.6824

Abstract

Oral lichen planus (OLP) have become a serious problem for health system. Curcuma longa (C. longa) is recognized as a medicinal plant with numerous biological properties. Hence, this study was conducted to review the effect of C. longa and its derivatives, curcumin and curcuminoids in treatment of OLP. This study followed systematic review design. We used the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements. To perform this study, we searched Scopus, PubMed/Medline, Web of Science and Google Scholar tools using appropriate keywords including “oral lichen planus”, ” turmeric”, ” Curcuma longa”, “curcumin” and “curcuminoids”. The search was limited to English articles. In this study, all studies published until May 2023 were used.  Of 76 identified articles from searching, 16 studies including 10 randomized controlled trials (RCTs), two case- controls and one case report were included in this systematic review. The sample size in these studies was 570 patients. Furthermore, most of these studies was done in India, Iran and USA. Taking together, turmeric and its derivatives curcumin and curcuminoids play important role in treatment of OLP. Indeed, its antioxidant and anti-inflammatory characteristics are probably responsible for therapeutic effects of turmeric and its derivatives. However, further studies are recommended for explaining therapeutic mechanisms of these compounds.

Keywords

References

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Caspian Journal of Environmental Sciences

Articles in Press, Corrected Proof
Available Online from 01 July 2023

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