Anticancer potential of Rhus coriaria L. (Sumac): A mini review

Document Type : Reviewers

Authors

1 Department of Clinical Science, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Department of Biology, Faculty of Basic Sciences, Mazandaran University, Babolsar, Iran

3 Department of Surgery, Shahrekord University of Medical Sciences, Shahrekord, Iran

4 Department of Midwifery, Sirjan School of Medical Sciences, Sirjan, Iran

5 Department of Food Science and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6 Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran

7 Department of Food Hygiene, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

10.22124/cjes.2023.6701

Abstract

Cancer is the biggest public health problem and the third leading cause of death in Iran. A healthy diet and daily consumption of natural antioxidants can help prevent cancer. Natural antioxidants have been recommended for a variety of health benefits due to their ability to scavenge free radicals, reactive derivatives, reducing oxidative stress and related damages. Rhus coriaria L. is rich in antioxidant compounds. Its anti-cancer effects have been documented in many in vitro and in vivo studies involving several cell lines and animal models. It inhibits carcinogens by inducing apoptosis, inhibiting cell proliferation, inhibiting oxygen species (ROS), and reducing tumour size. On the other hand, the high toxic effect of R. coriaria on cancer cells is associated with few or no side effects or damage to normal cells. Accordingly, this review provides an overview of recent advances in the use of R. coriaria against various types of cancer along with mechanisms of action. In addition, the present study summarizes R. coriaria as an anti-cancer agent and evaluates the potential of this natural compound as a complementary or alternative drug for cancer prevention and treatment.

Keywords

References

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Caspian Journal of Environmental Sciences

Articles in Press, Corrected Proof
Available Online from 09 June 2023

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