Effects of the silver nanoparticle synthesis from the leaves of the Capparis spinosa plant on the liver of mice infected with visceral leishmaniasis

Document Type : Research Paper

Authors

Department of Biology, College of Science, AL-Mustansiriyah University, Iraq

10.22124/cjes.2022.5765

Abstract

To know the effect of the Capparies silver nanoparticles (AgNPs) synthesis from the leaves of the Capparis spinosa plant on the liver enzymes GOT, GPT and the histology of the liver in infected mice with visceral leishmaniasis (VL), they were dosed with 0.1 mL day-1 and pentostam drug (0.01 mL day-1) for 21 days. The results showed that the silver nanoparticles of the Capparies spinosa, led to a significant decrease in liver enzymes, i.e., GOT and GPT after three weeks, compared to the positive control group. Also, it was noted that the liver tissue was less affected with a slight expansion of the hepatic sinusoids and a decrease in lymphocyte infiltration.

Keywords


Ahmad, A, Mukherjee, P, Senapati, S, Mandal, D, Khan, M, Kumar, R & Sastry, M 2003, Extracellular biosynthesis of silver nanoparticles using the fungus Fusarium oxysporum. Colloids and Surfaces Biointerfaces, 28: 313-318.
Allahverdiyev, AM, Abamor, ES, Bagirova, M, Ustundag, CB, Kaya, C, Kaya, F & Rafailovich, M 2011, Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light. International Journal of Nanomedicine, 6: 2705. ‏
Bagherzadeh Lakani, F, Meshkin, S, Yazdani Sadati, MA & Falahatkar, B 2016, Bioaccumulation of copper nanoparticle in gill, liver, intestine and muscle of Siberian sturgeon (Acipenser baerii) juvenile. Caspian Journal of Environmental Sciences, 14: 105-115.
Benakashani, F, Allafchian, AR & Jalali, SAH 2016, Biosynthesis of silver nanoparticles using Capparis spinosa L. leaf extract and their antibacterial activity. Karbala International Journal of Modern Science, 2: 251-258. ‏
Cabezas, Y, Legentil, L, Robert Gangneux, F, Daligault, F, Belaz, S, Nugier Chauvin, C & Ferrières, V 2015, Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates. Organic and Biomolecular Chemistry, 13: 8393-8404. ‏
Dameh, M, Ameen Baqer, A, Zaidi, M, K. Hachim, SM, Hameed, NA, Awadh, S, Obaid, AJ, Adhab, ZH 2022, Evaluating the efficacy of flavonoids from Capparis spinosa extracts in treatment of Candida vulvovaginitis. Caspian Journal of Environmental Sciences, 20: 565-570.
de Freitas, EO, Leoratti, FMDS, Freire de-Lima, CG, Morrot, A & Feijó, DF 2016, The contribution of immune evasive mechanisms to parasite persistence in visceral leishmaniasis. Frontiers in Immunology, 7: 153. ‏
Fayaz, AM, Balaji, K, Girilal, M, Yadav, R, Kalaichelvan, PT & Venketesan, R 2010, Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: a study against gram-positive and gram-negative bacteria. Nanomedicine: Nanotechnology, Biology and Medicine, 6:103-109. ‏
Ferreira, C, Mesquita, I, Barbosa, AM, Osório, NS, Torrado, E, Beauparlant, CJ & Silvestre, R 2020, Glutamine    supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis. PLoS Neglected Tropical Diseases, 14: e0008125,‏ https://doi.org/10.1371/journal.pntd.0008125.
Ghazanfari, S, Rahimi, R, Zamani-Ahmadmahmood, R, Momeninejad, A & Abed-Elmdoust, A 2020, Impact of silver nanoparticles on hepatic enzymes and Thyroid hormones in Swai (Pangasius hypophthalmus). Caspian Journal of Environmental Sciences, 18: 265-275
Hamed, AR, Abdel Shafeek, KA, Abdel Azim, NS, Ismail, SI & Hammouda, FM 2007, Chemical investigation of some Capparis species growing in Egypt and their antioxidant activity. Evidence-Based Complementary and Alternative Medicine, 4: 25-28. ‏
 Johari, SA, Asghari, S & Je Yu, Il 2016, Toxicity of various silver nanoparticles compared to silver ions in the Ponto-Caspian amphipod Pontogammarus maeoticus (Sowinsky, 1894). Caspian Journal of Environmental Sciences, 14: 25-32.
Kaye, PM, Svensson, M, Ato, M, Maroof, A, Polley, R, Stager, S, Zubairi, S & Engwerda, CR 2004, The immunopathology of experimental visceral leishmaniasis. Immunological Reviews, 20: 239-253. ‏
Mathur, P, Samantaray, JC & Samanta, P 2008, High prevalence of functional liver derangement in visceral leishmaniasis at an Indian tertiary care centre. Clinical Gastroenterology and Hepatology, 6: 1170-1172. ‏
Maurer, M & Dondji, B & von Stebut, E 2009, What determines the success or failure of intracellular cutaneous parasites? Lessons learned from leishmaniasis. Medical Microbiology and Immunology, 198:137-146. ‏
Mohamed, ST, Ghadi, HH, Kamal, SB, Mohammed, N & Aja, HA 2019, Effect of Fusarium graminarum silver nanoparticles on liver tissue of infected mice of visceral leishmaniasis. Journal of Pharmaceutical Sciences and Research, 11: 886-891. ‏
Morimoto, A, Omachi, S, Osada, Y, Chambers, JK, Uchida, K, Sanjoba, C & Goto, Y 2016, Hemophagocytosis in experimental visceral Leishmaniasis by Leishmania donovani. PLoS Neglected Tropical Diseases, 10: e0004505.
Naseralla, BA, Al Quraishi, MA & Jebur, MS 2015, Serological detection and liver functions of pediatric visceral leishmaniasis in Baghdad hospitals. International Journal of Current Microbiology and Applied Sciences, 4: 100-107. ‏
Parang, Z & Moghadamnia, D 2018, Effects of silver nanoparticles on the functional tests of liver and its histological changes in adult male rats. Nanomedicine Research Journal, 3: 146-153. ‏
Prajapati, R, Kumar, A, Sharma, P, Singla, V, Bansal, N, Dhawan, S & Arora, A 2016, A rare presentation of Leishmaniasis. Journal of Clinical and Experimental Hepatology, 6: 146-148.
Saleem, K, Khursheed, Z, Hano, C, Anjum, I & Anjum, S 2019, Applications of nanomaterials in leishmaniasis: a focus on recent advances and challenges. Nanomaterials, 9: 1749. ‏
Stamplecoskie, KG & Scaiano, JC 2010, Light emitting diode irradiation can control the morphology and optical properties of silver nanoparticles. Journal of the American Chemical Society, 132: 1825-1827. ‏
Tesfanchal, B, Gebremichail, G, Belay, G, Gebremariam, G, Teklehaimanot, G, Haileslasie, H, Kahsu, G, Gebrewahd, A, Mardu, F, Adhanom, G, Berhe, B, Teame, H, Tsegaye, A & Wolde, M 2020, Alteration of clinical chemistry parameters among visceral leishmaniasis patients in Western Tigrai, Ethiopia, 2018/2019: A Comparative Cross-Sectional Study. Infection and Drug Resistance, 13: 3055-3062.
Thirumagal, N & Jeyakumari, AP 2020, Structural, optical and antibacterial properties of green synthesized silver nanoparticles (AgNPs) using Justicia adhatoda L. leaf extract. Journal of Cluster Science, 31: 487-497. ‏
WHO 2010, Report of a Meeting of the WHO Expert Committee on the Control of Leishmaniases. Expert Committee on the Control of the Leishmaniases, Meeting, World Health Organization. Geneva, 22-26 March 2010 (No. 949).