Effect of smoking on infection with COVID-19

Document Type : Research Paper


Department of Biology, College of Education for pure Sciences, Kerbala University, Kerbala, Iraq



The appearance of the pandemic (COVID-19) encourage researchers to carry out a lot of studies to study the effect of different factors on the severity of the infection; among them are smoking, chronic diseases, age, gender. The aim of the current study was to study the significance of smoking, chronic disease, gender and age factors with the severity of infection with Coronavirus and the need to ICU.   The study was carried out in Imam Hussein Teaching Hospital in Karbala, Iraq on both genders, from January to April 2021. The collected information from patients included gender, age, smoking, chronic diseases (high blood pressure, diabetes, other diseases) and the needs for ICU. The result was presented in five tables; the significance between the factors were considered important at p< 0.001. In conclusion, several important points were the outcomes of the current study: smokers are highly risked with Coronavirus; no significant correlation was found between gender and medication with the risk of COVID-19; a significant correlation was observed between the duration of smoking and severity with COVID-19.


Alqahtani, JS, Oyelade, T, Aldhahir, AM, Alghamdi, SM & et al 2020, Prevalence, severity and mortality associated with COPD and smoking in patients with COVID-19: a rapid systematic review and meta-analysis. Plos One Journal, 15: e0233147, https://doi.org/10.1371/journal.pone.0233147.
Arcavi, L & Benowitz, NL 2004, Cigarette smoking and infection. Archives of Internal Medicine, 164: 2206-2216.
Bendaif, H, Hammouti, B, Stiane, I, Bendaif, Y, El Ouadi, M, A, El Ouadi, Y 2020, Investigation of spread of novel coronavirus (COVID-19) pandemic in Morocco & estimated confinement duration to overcome the danger phase. Caspian Journal of Environmental Sciences, 18: 149-156
Chang, SA 2012, Smoking and type 2 diabetes mellitus. Diabetes & Metabolism Journal, 36: 399-403, DOI: 10.4093/dmj.2012.36.6.399.
Changeux, JP, Amoura, Z, Rey, FA & Miyara, MA 2020, Nicotinic hypothesis for covid-19 with preventive and therapeutic implications. Comptes Rendus Biologies, 343: 3-39.
Dhillon, P, Breuer, M & Hirst, N 2020, Covid-19 breakthroughs: separating fact from fiction. The FEBS Journal, Available from: https://doi.org/10.1111/febs.15442.
Docherty, AB, Harrison, EM, Green, CA, Hardwick, HE & et al. 2020, Isaric4c investigators. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC who clinical characterisation protocol: prospective observational cohort study. BMJ, 369:m1985, https://doi.org/10.1136/bmj.m1985.
 Farsalinos, K, Barbouni, A & Niaura, R 2020, Systematic review of the prevalence of current smoking among hospitalized COVID-19 patients in China: could nicotine be a therapeutic option. Internal and Emergency Medicine. 9: 1-8, https://doi.org/10.1007/s11739-020-02355-7.
Farsalinos, K, Niaura, R, Le Houezec, J & et al. 2020, Editorial: nicotine and sars-cov-2: covid-19 may be a disease of the nicotinic cholinergic system. Toxicology Research, 7:658-663.
Geng, JS, Yu, XL, Bao, HN, Feng, Z & et al. 2021, Chronic diseases as a predictor for severity and mortality of covid-19: a systematic review with cumulative meta-analysis. Frontiers in Medicine, 8:1442. DOI=10.3389/fmed.2021.588013.
Giannouchos, TV, Sussman, RA, Mier, JM, Poulas, K & Farsalinos, K 2021, Retraction notice for: "Characteristics and risk factors for COVID-19 diagnosis and adverse outcomes in Mexico: an analysis of 89,756 laboratory-confirmed COVID-19 cases." European Respiratory Journal. 4: 57(3): 2002144, DOI: 10.1183/13993003.02144-2020.
Guan, WJ, Ni, ZY, Hu, YM & et al. 2020, Clinical characteristics of coronavirus disease 2019 in china. New England. Journal of Medicine, 382: 1708-1720.
Hiroki, U, Toshiki, K, Hisato, T, Parasuram, K & et al. 2020, Gender difference is associated with severity of coronavirus disease 2019 infection: an insight from a meta-analysis. Critical Care Explorations, 2: e0148. DOI: 10.1097/CCE.0000000000000148
Hu, Y, Chen, Q & Zhang, B 2021, Can chronic disease diagnosis urge the patients to quit smoking?  evidence from the china health and nutrition survey. Risk Management and Healthcare Policy, 14: 059-3077, https: //doi.org/10.2147/RMHP.S315358.
Jaber, AS, Hussein, AK, Kadhim, NA, bojassim, AA 2022, A Moran’s I autocorrelation and spatial cluster analysis for identifying Coronavirus disease COVID-19 in Iraq using GIS approach. Caspian Journal of Environmental Sciences, 20: 55-60.
Jin, JM, Bai, P, He, W, Wu, F, Liu, XF & et al. 2020, Gender differences in patients with covid-19: focus on severity and mortality. Frontiers in Public Health, 8: 152. DOI: 10.3389/fpubh.2020.00152.
Khadom, A, Khudhair Al-Jiboory, AS Mahdi, MB & Mahood, H 2021, Regression and validation studies of the spread of novel COVID-19 in Iraq using mathematical and dynamic neural networks models: A case of the first six months of 2020. Caspian Journal of Environmental Sciences, 19: 431-440
Luk, TT & et al. 2020, Exposure to health misinformation about covid-19 and increased tobacco and alcohol use: a population-based survey in Hong Kong. Tob Control Journal, https://doi.org/10.1136/tobaccocontrol-2020-055960.
Maliki, I, Elmsellem, H, Hafez, B, EL Moussaoui, A, Reda Kachmar, M, Ouahbi, A 2021, The psychological properties of the Arabic BDI-II and the psychological state of the general Moroccan population during the mandatory quarantine due to the COVID-19 pandemic. Caspian Journal of Environmental Sciences, 19: 139-150.
Paola, P, Emanuela, F, Sunjai, G, Michael, GM & Neil RP 2001, Association between smoking and blood pressure, Journal of Hypertension, 37: 187-193, DOI: 10.1161/01.HYP.37.2.187.
Patanavanich, R & Glantz, SA 2020, Smoking is associated with covid-19 progression: a meta-analysis. Nicotine & Tobacco Research, 24:1653-1656, DOI: 10.1093/ntr/ntaa082.
Rossato, M, Russo, L, Mazzocut, S, Di Vincenzo, A, Fioretto, P & Vettor, R 2020, Current smoking is not associated with COVID-19. European Respiratory Journal. 4: 55. DOI: 10.1183/13993003.01290-2020.
Simons, D, Shahab, L, Brown, J & Perski, O 2020, The association of smoking status with Sars‐Cov‐2 infection, hospitalization and mortality from covid‐19: a living rapid evidence review with Bayesian meta-analyses (version 7). Addiction, https://doi.org/10.1111/add.15276.
Sulandjari, K, Putra, A, Sulaminingsih, S, Adi Cakranegara, P, Yusroni, N, Andiyan, A 2022, Agricultural extension in the context of the Covid-19 pandemic: Issues and challenges in the field. Caspian Journal of Environmental Sciences, 20: 137-143.
Vardavas, CI & Nikitara, K 2020, COVID-19 and smoking: A systematic review of the evidence. Tob Induction Disease, 20: 18-20, DOI: 10.18332/tid/119324.