University of Guilan Caspian Journal of Environmental Sciences 1735-3033 24 3 2026 07 01 Review of functions of the lymphatic system in cavity of abdominal inflammation 865 872 9799 10.22124/cjes.2026.9799 EN Nazym Issayeva Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan Aigul Mamataeva Department of Biology, Kazakh National Women's Pedagogical University, Almaty, Kazakhstan Gulshat Atanbaeva Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan Botakoz Joltukova Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan Anar Yeshmukhanbet Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan Makpal Yessenova Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan Ulbossin Kozhaniyazova Laboratory of Physiology Lymphatic System, Institute of Genetics and Physiology SC MSHE RK, Almaty, Kazakhstan 0000-0001-6122-0320 Serik Abdreshov Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan Journal Article 2026 07 30 Despite long being thought of as a passive clearing system, the abdominal lymphatics have recently shown themselves as active regulators of inflammatory outcomes. This systematic review attempts to synthesize currently available information on lymphatic functional changes during different stages of peritoneal inflammation, based especially on studies carried out in Kazakhstan from 2022 to 2025. We conducted a systematic literature search in PubMed, Scopus, Web of Science, and regional Central Asian databases up to September 2025 and identified 62 studies reporting on quantifiable lymphatic drainage, node morphological, or lymph cytokine changes. Our analysis indicates the differences in impact caused by inflammatory types, whereby acute bacterial peritonitis led to reduced mesenteric pumping to mere 32% of control values along with a seven-fold increase in lymph TNF α, whereas inflammatory bowel disease enabled increased drainage (up to 55%) at the expense of severe nodal hyperplasia. The inverse association between lymphatic flow and time taken by systemic inflammatory response syndrome persisted across all groups (mean <em>r</em> value of 0.69). Moreover, in the Kazakhstani multicenter study, for each 10% decrease in pump amplitude, there was an additional ten hours added to the clinical improvement period—a dose-dependent association with direct prognostic implications. Regarding methodologies employed, molecular assessment of the lymphatic fluid performed better than imaging and pathologic methods in the assessment of dysfunction at a very early stage, indicating that molecular markers predate morphological findings. Taken together, all this research poses significant questions against the existing passive drainage hypothesis, highlighting mesenteric lymphatic pumps as a potential underused therapeutic approach for treating abdominal inflammation. Nevertheless, lack of established bedside testing techniques, as well as the fact that studies have been mainly cross-sectional, necessitates further interventional research. https://cjes.guilan.ac.ir/article_9799_dcae7d65080ec5c5fc2148b826fdd860.pdf