University of Guilan Caspian Journal of Environmental Sciences 1735-3033 24 2 2026 04 01 Influence of butylcaptax and Dropp on the phospholipid composition and lipid peroxidation (LPO) in the liver mitochondria and microsomes of pregnant rats and their embryos 305 318 9616 10.22124/cjes.2026.9616 EN Dilfuza Tuychiyeva Department of Biological Chemistry and Pharmacy, Andijan Branch of Kokand University, Andijan Parida Mirkhamidova Department of Biology, Faculty of Natural Sciences, National Pedagogical University of Uzbekistan named after Nizami, Tashkent City, Uzbekistan Gulnara Shakhmurova Department of Biology, Faculty of Natural Sciences, National Pedagogical University of Uzbekistan named after Nizami, Tashkent City, Uzbekistan Rano Alimova Department of Biochemistry and Physiology, Tashkent State Agrarian University, Tashkent State Agrarian University, Tashkent region, Uzbekistan Gafurzhon Mukhamedov Rector of Chirchik State Pedagogical University, Tashkent, Uzbekistan Xusniddin Karimov The Department of microbiology, immunology and virology, Andijan Branch of Kokand University, Andijan Nurxon Moydinova Department of Microbiology, Immunology and Virology, Andijan Branch of Kokand University, Andijan, Uzbekistan Mavjuda Rakhmatullayeva Department of Inorganic, Physical and Colloidal chemistry, Tashkent Pharmaceutical Institute, Tashkent, Uzbekistan Maxliyo Sattorova Psychology Department, Termez State University. Termez, Uzbekistan Salomat Almardanova Psychology Department, Termez State University. Termez, Uzbekistan Journal Article 2026 05 18 This study investigates the effects of the defoliants butylcaptax and Dropp on the phospholipid composition and lipid peroxidation (LPO) in the liver mitochondria and microsomes of pregnant rats and their embryos. Experiments were conducted on Wistar rats exposed to 1/10 of the LD₅₀ dose on gestation days 3, 13, and 19. The results demonstrated a decrease in phosphatidylethanolamine and total phospholipid content, along with an increase in phosphatidic acid, lysophospholipids, and the cholesterol/phospholipid ratio. A significant enhancement of both enzymatic and non-enzymatic LPO was observed in the mitochondria and microsomes, with more pronounced effects following butylcaptax exposure. Although embryonic tissues exhibited less marked alterations, similar trends were observed. The findings indicate the activation of lipid peroxidation processes and the disruption of membrane structures, which may contribute to embryotoxic effects. https://cjes.guilan.ac.ir/article_9616_0ad8bfb50f4c570b0b96b9b81794ea8b.pdf