University of Guilan Caspian Journal of Environmental Sciences 1735-3033 22 2 2024 04 01 Antidiabetic and antioxidant effects of sage tea, Salvia officinalis in male rats exposed to hydrogen peroxide as a source of reactive oxygen species 453 457 7478 10.22124/cjes.2024.7478 EN Sahib M.H. Mohammad Bakir Dentistry College/ Al-Bayan University, Baghdad, Iraq Sadiq M. A. Al-Hiti College of Pharmacy, Baghdad, Iraq Rajiha A. S. Al-Naimi College of Veterinary Medicine Baghdad University, Baghdad, Iraq Dina T. Ali Institute of Embryonic Research and Infertility Treatment, Iraq Journal Article 2024 01 23 The antidiabetic and antioxidant effects of <em>Salvia officinalis</em> (sage tea) were studied in 20 mature male rats for 42 days. The rats were divided into four equal groups and given the following treatments: group one as a control group (C), rats only received tap water; group two (T₁) received 0.5% H₂O₂ as a source of reactive oxygen species (ROS); group three (T₂) received sage tea as 2 mg sage in 150 mL boiling water (ad libitum); and group four (T₃) received 400 IU/Kg BW/day vitamin E by oral intubation along with 0.5% H₂O₂. In order to determine serum glucose levels, blood samples were taken directly from the heart after the end of the experiment. Rats were slaughtered, and pancreas samples were collected for patho-histological analysis. The serum glucose levels in the sage tea with the H₂O₂ group (T₂) and T₃ as compared to the second group (T₁) showed a significant decrease (p ˂ 0.05). Histological examination revealed significant recovery of the pancreatic tissues especially islets of Langerhans in sage tea and vitamin E rats (T₃). This investigation suggests the antidiabetic effect of sage tea for H₂O₂- induced diabetic rats mediated by their effect as antioxidants. https://cjes.guilan.ac.ir/article_7478_4bc25791753411669d85ab77048abc1d.pdf